Potent Effect of Phlorotannins Derived from Sargassum linifolium as Antioxidant and Antidiabetic in a Streptozotocin-Induced Diabetic Rats Model

Phlorotannins are phenolic compounds existing in large amounts Phaeophyta, with this amount differing according to the season and collection area. There many pharmacological properties of phlorotannins, such as being antioxidant, antidiabetic, anti-cancer. In work, phlorotannins from Phaeophyta Sargassum linifolium were extracted, characterized, identified, for use an antioxidant anti-diabetic a streptozotocin-induced diabetes rat model. Phlorotanins characterized using ultraviolet (UV) Fourier transform infrared (FT-IR) analysis, dimethoxy benzaldehyde assay (DMBA), Folin–Ciocalteu assays. Groups rats tested follows: normal control (negative control) (G1), treated 60 mg/kg body weight (G2), positive diabetic injected one dose streptozotocin (G3), group at mg kg−1 (G4). The biochemical parameters determined after 4 weeks treatment. results demonstrated that extracted compound was phlorotannin, which had properties. An vivo study confirmed glucose insulin levels G4 relatively similar those G1. glucosidase, alpha-amylase, glutathione, catalase 0.11 ± 0.097, 420.5 13, 11.27 3.3, 8.01 1.31 µmol/min/g G1, 0.04 0.016, 184.75 55.24, 12.78 2.1, 11.28 1.74 µmol/min/g) G4, respectively. no side effects kidney function both G2 cholesterol triglyceride also normal. have activated AMPK expression. According histological improved islet size reversed necrotic fibrotic alterations pancreas. present suggest derived study. They could be used developing medicinal preparations treating its related symptoms.